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R novel genetic loci have been associated with SLE susceptibility that may or may not function within immune system pathways and have no known previous relationship to the pathogenesis of SLE. Examining the list of genes associated with SLE, there is a remarkable overrepresentation of genes involved in type I interferon (IFN) signaling, production, and response [13, 14]. Interferon alpha (IFN-) is
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Ment in other energetic demands, such as reproduction or physical activity, also evidence trade-offs with nonacute immune function? Intriguingly, two recent studies support a hypothesis that there are some trade-offs between female reproductive function and higher levels of CRP. Though they do not| Shattuck-Heidorn et al.Evolution, Medicine, and Public Healthspecifically investigate non-acute CRP,
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